The earliest known synthesizer (literally, a machine which makes sounds synthetically) was built in 1906 by an inventor named Thaddeus Cahill. Cahill’s music machine is said to have weighed 200 tons and required twenty railroad boxcars to transport. Needless to say, the gargantuan gadget proved impractical.

Helen Epstein

The New York Times Arts and Leisure section, Sunday, July 21, 1974.